Anaplastic Large Cell Lymphomas Expressing the Novel Chimeric Protein P80NPM’ALKo
نویسندگان
چکیده
Anaplastic large cell lymphoma (ALCL) is a subtype of nonHodgkin‘s lymphoma characterized by the CD30’ large neoplastic cells and sometimes carries a t(2;5)(p23;q35). Recently, we found a novel hyperphosphorylated 80-kD protein tyrosine kinase, p80, in ALCLs with t(2;5). Subsequent cDNA cloning showed p80 to be a fusion protein of two genes, the novel tyrosine kinase gene and the nucleophosmin gene, in accordance with the sequence of the NPM/ALK gene (Morris et al. Science 263:1281, 1994). Meanwhile, the clinicopathologic features of p8O-carrying ALCLs have remained unclear. Paraffin sections of 105 cases of ALCL were immunostained
منابع مشابه
Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction.
The t(2;5)(p23;q35) translocation was initially identified in cases of anaplastic large-cell lymphoma (ALCL) that expressed the Ki-1 (CD30) antigen. We have recently cloned this translocation and shown it to encode a chimeric product consisting of the N-terminal portion of a nonribosomal nucleolar phosphoprotein, nucleophosmin (NPM), from chromosome 5, fused to the kinase domain of a novel tran...
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